I use the synthetic, powderless ones. They're strong as hell and don't squeeze my poor, tired little fingers at all. I have super sensitive skin and every winter I have lots of problems with cracking and bleeding digits. A good greasing (plain Vaseline is what my dermatologist suggested) before putting on the gloves for a long developing or darkroom session usually sets me up and I find my problems far less troublesome all winter long. I used to have to sleep with greased hands in gloves all night - not nice. Now, the more darkroom work I do, the better my hands feel.