I have the Porter case (http://www.portercase.com/) and love it. Whilst I carry medium format equipment in it instead of large, there's no reason it can't be reconfigured for whatever you want to carry. It comes with a set of Velcro-attached padded dividers, so you can move them as you need them. It also has the advantage that it converts into a hand truck to carry your checked luggage around the airport. I've carried it on many airplanes and have never had a problem fitting it into overheads.