Just converting from conductivity to vAg will change the excess halide available to diffuse into the developer at the start of the process. Using an organic antifoggant or antioxidant instead of Sodium Sulfite in an overcoat will change emulsion properties and use of Thiosulfate as sensitizer instead of Thiocyanate will change the properties.
Modern sensitizing dyes are quite different than the early dyes and we both know that. Examples are modern cyanines and merocyanines and earlier ones include many ortho dyes instead of pan dyes. Erythrosine comes to mind here.
So, I'm sure with some thought, we all could come up with a long long list of simple differences that are quite well known having been posted here before and posted elsewhere.