What goes out the door with me every day:
Domke F-5XB RuggedWear
Leica M6 Panda
Leitz Summicron 35mm IV
Leitz Summicron 50mm III
A few rolls of Tri-X, Ilford XP2 or BW400CN
A roll or two of color negative film
Minolta Auto Meter V F
B+W color filters: 023 Yellow/Orange, 061 Green, 041 Red
Kodak 5x4" gray/white card
Extra battery for M6
Wallet, iPhone, Business cards

Ocasionally I'll bring along a DSLR and that will add (to my shoulder):
Canon 20D
Contax Zeiss 28/2.8
Shimada C/Y-to-EOS adapter
and a
Shimada C/Y-to-M adapter in the bag

If I need super wide, I'll put the 10-22 on the 20D and just stow the Zeiss 28mm and adapters for use on either body.

I have other bags like a large f.64 and a Lowepro EliteAW for larger assignments but lately I've been all about the small Domke, one body and two lenses.