Set the expopsure, guess the distance and away you go.
It's true! You learn to guess distances very quickly with these cameras - I should know, since the first "focussable" camera I used was a 35mm folder.
If possible, stop down to f:16 or so to take advantage of the DOF. Also the lenses are sharpest at about this setting (unless you've got one with a Tessar lens, which is sharp all over).